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The pharmacokinetic differences between short-acting and long-acting analogues have profound implications for the mode of action, efficacy, and tolerability of these compounds

10.1111/j.1432-1033.1990.tb19419.x

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Recent improvements in molecular modeling have enabled the design of new inhibitors with higher selectivity for DPP-4 than for other dipeptidyl peptidases, thus minimizing side effects [28]

Liver and visceral fat also decreased significantly [4]

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